Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ABAT | P80404 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL976297 | 1.00 | POLB (0.38) | POLBTDP1APEX1LMNAKDM4E | |
| Acetic Acid SCHEMBL539228 | 0.88 | POLB (0.40) | POLBTDP1APEX1LMNAKDM4E | |
| SCHEMBL820392 | 0.88 | KDM4E (0.33) | POLBTDP1APEX1LMNAKDM4E | |
| SCHEMBL2478423 | 0.84 | POLB (0.32) | POLBTDP1APEX1 | |
| SCHEMBL22982714 | 0.84 | KDM4E (0.33) | POLBTDP1APEX1LMNAKDM4E | |
| SCHEMBL6065835 | 0.83 | — | — | |
| SCHEMBL4967707 | 0.83 | — | — | |
| SCHEMBL22129636 | 0.83 | — | — | |
| SCHEMBL11183068 | 0.83 | — | — | |
| Glycine SCHEMBL20659283 | 0.82 | GLRA1 (0.48) | POLBTDP1APEX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050122-A1 | COPOLYMERS OF VINYL PHOSPHONIC ACID AS AN ADDITIVE IN CROSS-LINK CURING PAINT FORMULATIONS | BASF SE (DE) | 2009-04-23 | — | — | WO | disclosed |