Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL976297 | 0.88 | POLB (0.38) | POLBTDP1APEX1KDM4ELMNA | |
| Bicarbonate SCHEMBL4270205 | 0.88 | POLB (0.38) | POLBTDP1APEX1KDM4ELMNA | |
| Methacrylic Acid SCHEMBL18342808 | 0.85 | TDP1 (0.34) | POLBTDP1APEX1LMNA | |
| Methacrylic Acid SCHEMBL372591 | 0.85 | TDP1 (0.34) | POLBTDP1APEX1LMNA | |
| Methacrylic Acid SCHEMBL20873030 | 0.84 | POLB (0.33) | POLBTDP1APEX1LMNA | |
| Phenol SCHEMBL928808 | 0.83 | CA12 (0.42) | POLBTDP1LMNA | |
| SCHEMBL820392 | 0.82 | KDM4E (0.33) | POLBTDP1APEX1KDM4ELMNA | |
| SCHEMBL1477532 | 0.82 | TP53 (0.33) | POLBTDP1APEX1 | |
| SCHEMBL21433605 | 0.82 | ALDH1A1 (0.48) | POLBTDP1APEX1 | |
| Propionic Acid SCHEMBL943966 | 0.82 | FFAR3 (0.48) | POLBTDP1APEX1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7148302-B2 | Polymerizing a norbornene-functional monomer in a solvent in the presence of a catalyst system: consists (a) palladium or a palladium compound (b) a compound selected from fluorinated alcohols, fluorinated acids, and ionic liquids | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2006-12-12 | — | — | US | claimed |
| US-7122611-B2 | Catalyst for polymerization of norbornene | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2006-10-17 | — | — | US | claimed |
| US-20060173143-A1 | Catalyst for polymerization of norbornene | THE GOODYEAR TIRE & RUBBER COMPANY | 2006-08-03 | — | — | US | claimed |
| US-20060074206-A1 | Catalyst for polymerization of norbornene | THE GOODYEAR TIRE & RUBBER COMPANY | 2006-04-06 | — | — | US | claimed |
| EP-3317247-A1 | PROCESS FOR PREPARING POLYOLS | Pivert S.A.S. (FR) | 2018-05-09 | — | — | EP | disclosed |
| EP-1563001-B1 | NEGATIVE C-PLATE TYPE OPTICAL ANISOTROPIC FILM COMPRISING POLY CYCLOOLEFIN AND METHOD FOR PREPARING THE SAME | LG CHEMICAL LTD (KR) | 2017-11-01 | — | — | EP | disclosed |
| CN-102585069-B | Method for preparing norbornene monomer composition, norbornene polymer prepared therefrom, optical film comprising the norbornene polymer, and method for preparing the norbornene polymer | LG CHEMICAL CO., LTD. (KR) | 2014-10-22 | — | — | CN | disclosed |
| US-8778846-B2 | Composition, device and associated method | GENERAL ELECTRIC COMPANY (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778845-B2 | Composition, device and associated method | GENRAL ELECTRIC COMPANY (US) | 2014-07-15 | — | — | US | disclosed |
| US-8765643-B2 | Composition, device and associated method | GENERAL ELECTRIC COMPANY (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2523039-B1 | Unified polarizing plate and method for preparing the same | LG CHEMICAL LTD (KR) | 2014-06-25 | — | — | EP | disclosed |
| US-8741813-B2 | Composition, device and associated method | GENERAL ELECTRIC COMPANY (US) | 2014-06-03 | — | — | US | disclosed |
| EP-1563001-A2 | NEGATIVE C-PLATE TYPE OPTICAL ANISOTROPIC FILM COMPRISING POLY CYCLOOLEFIN AND METHOD FOR PREPARING THE SAME | LG Chem, Ltd. (KR) | 2005-08-17 | — | — | EP | disclosed |
| US-20050014913-A1 | Negative c-plate type optical anisotropic film comprising poly cycloolefin and method for preparing the same | LG CHEM, LTD. (KR) | 2005-01-20 | — | — | US | disclosed |
| EP-1476784-A1 | UNIFIED POLARIZING PLATE AND METHOD FOR PREPARING THE SAME | LG Chem, Ltd. (KR) | 2004-11-17 | — | — | EP | disclosed |
| WO-2004070463-A1 | UNIFIED POLARIZING PLATE AND METHOD FOR PREPARING THE SAME | LG CHEM, LTD. (KR) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004049011-A2 | NEGATIVE C-PLATE TYPE OPTICAL ANISOTROPIC FILM COMPRISING POLY CYCLOOLEFIN AND METHOD FOR PREPARING THE SAME | LG CHEM, LTD. (KR) | 2004-06-10 | — | — | WO | disclosed |
| EP-0374410-A2 | 2-Azabicyclo[2.2.1]hept-5-ene-2-acetic acid, derivatives thereof and related compounds, process for the preparation of said compounds and the use of said compounds for the manufacture of N-phosphonomethylglycine | AMERICAN CYANAMID COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |
| US-4781977-A | WATER-INSOLUBLE RESIN-SPACER-LIGAND | SANRAKU INCORPORATED (JP) | 1988-11-01 | — | — | US | disclosed |
| EP-0220719-A2 | Cyclodextrin absorbing material and its use | Sanraku Incorporated (JP) | 1987-05-06 | — | — | EP | disclosed |