SCHEMBL820392

SCHEMBL820392

C1=CC2CCC1C2.O=C(Cl)Cl

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.32
APEX1 P27695 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL976297 0.88 POLB (0.38) KDM4ELMNAPOLBAPEX1TDP1
Bicarbonate SCHEMBL4270205 0.88 POLB (0.38) KDM4ELMNAPOLBAPEX1TDP1
Acetone SCHEMBL29196109 0.85 POLB (0.36) KDM4ELMNAPOLBAPEX1TDP1
SCHEMBL28659608 0.84
SCHEMBL11183068 0.83
SCHEMBL22129636 0.83
SCHEMBL6065835 0.83
SCHEMBL36991 0.83
SCHEMBL29465206 0.83
Acetic Acid SCHEMBL539228 0.82 POLB (0.40) KDM4ELMNAPOLBAPEX1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112812139-A Asymmetric cobaltocene cation derivative and preparation method thereof 西北工业大学 2021-05-18 CN claimed
CN-112812139-A Asymmetric cobaltocene cation derivative and preparation method thereof 西北工业大学 2021-05-18 CN disclosed
CN-108368264-B Polyamide-imide, method for producing same, and polyamide-imide film using same 株式会社LG化学 2021-01-22 CN disclosed
CN-108431090-B High-strength transparent polyamide-imide and method for producing same 株式会社LG化学 2020-08-28 CN disclosed
CN-108368338-B High-strength transparent polyamide-imide and preparation method thereof 株式会社LG化学 2020-07-31 CN disclosed
US-8609745-B2 Production of ophthalmic devices based on photo-induced step growth polymerization NOVARTIS AG (CH) 2013-12-17 US disclosed
US-20130106007-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION NOVARTIS AG (CH) 2013-05-02 US disclosed
US-8357771-B2 Production of ophthalmic devices based on photo-induced step growth polymerization NOVARTIS AG (CH) 2013-01-22 US disclosed
EP-2092376-B1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION NOVARTIS AG (CH) 2012-10-17 EP disclosed
US-8207365-B2 Polymeric salen compounds and methods thereof GEORGIA TECH RESEARCH CORPORATION (US) 2012-06-26 US disclosed
US-20110269869-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION ALCON INC. (CH) 2011-11-03 US disclosed
US-8003710-B2 Production of ophthalmic devices based on photo-induced step growth polymerization NOVARTIS AG (CH) 2011-08-23 US disclosed
EP-2092376-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION Novartis Ag (CH) 2009-08-26 EP disclosed
US-20090030172-A1 POLYMERIC SALEN COMPOUNDS AND METHODS THEREOF GEORGIA TECH RESEARCH CORPORATION (US) 2009-01-29 US disclosed
WO-2008076729-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION NOVARTIS AG (CH) 2008-06-26 WO disclosed
US-20080143958-A1 Production of ophthalmic devices based on photo-induced step growth polymerization ALCON INC. (CH) 2008-06-19 US disclosed
WO-2006099162-A2 POLYMERIC SALEN COMPOUNDS AND METHODS THEREOF GEORGIA TECH RESEARCH CORPORATION (US) 2006-09-21 WO disclosed
US-20030087190-A1 Photosensitive formulation for buffer coatings, film including the formulation, and method for manufacturing electronics using the formulation SEZI RECAI (DE) 2003-05-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090030172-A1 POLYMERIC SALEN COMPOUNDS AND METHODS THEREOF F12, CHRM1, H1-0 KDM4E 3909/4885LMNA 233/4885POLB 1068/4885
US-20110269869-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION CRYAA, CRYZ, CRYAB KDM4E 3874/4885LMNA 1808/4885POLB 956/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.