Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ABAT | P80404 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4270205 | 1.00 | POLB (0.38) | POLBTDP1APEX1LMNAKDM4E | |
| Acetic Acid SCHEMBL539228 | 0.88 | POLB (0.40) | POLBTDP1APEX1LMNAKDM4E | |
| SCHEMBL820392 | 0.88 | KDM4E (0.33) | POLBTDP1APEX1LMNAKDM4E | |
| SCHEMBL2478423 | 0.84 | POLB (0.32) | POLBTDP1APEX1 | |
| SCHEMBL22982714 | 0.84 | KDM4E (0.33) | POLBTDP1APEX1LMNAKDM4E | |
| SCHEMBL6065835 | 0.83 | — | — | |
| SCHEMBL4967707 | 0.83 | — | — | |
| SCHEMBL22129636 | 0.83 | — | — | |
| SCHEMBL11183068 | 0.83 | — | — | |
| Glycine SCHEMBL20659283 | 0.82 | GLRA1 (0.48) | POLBTDP1APEX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111065966-B | Improved fill material for reducing pattern collapse | 霍尼韦尔国际公司 | 2023-12-05 | — | — | CN | claimed |
| CN-111133557-B | Thermally removable filler material for anti-stiction applications | 霍尼韦尔国际公司 | 2023-11-24 | — | — | CN | claimed |
| US-11396136-B2 | 3D printing support structures incorporating sacrificial materials | XEROX CORPORATION (US) | 2022-07-26 | — | — | US | claimed |
| CN-111133557-A | Thermally removable fill material for anti-stiction applications | 霍尼韦尔国际公司 | 2020-05-08 | — | — | CN | claimed |
| CN-111065966-A | Improved fill material for reducing pattern collapse | 霍尼韦尔国际公司 | 2020-04-24 | — | — | CN | claimed |
| US-20260033306-A1 | PROTECTION OF SENSITIVE SURFACES IN SEMICONDUCTOR PROCESSING | LAM RES CORP (US) | 2026-01-29 | — | — | US | disclosed |
| US-20250132195-A1 | METHODS AND FORMULATIONS FOR SACRIFICIAL BRACING, SURFACE PROTECTION, AND QUEUE-TIME MANAGEMENT USING STIMULUS RESPONSIVE POLYMERS | LAM RESEARCH CORPORATION | 2025-04-24 | — | — | US | disclosed |
| US-20240312778-A1 | TEMPORARY CAPPING MATERIAL FOR OXIDE PREVENTION IN LOW TEMPERATURE DIRECT METAL-METAL BONDING | LAM RESEARCH CORPORATION | 2024-09-19 | — | — | US | disclosed |
| CN-118043941-A | Methods and formulations for sacrificial support, surface protection and waiting time management using stimulus-responsive polymers | 朗姆研究公司 | 2024-05-14 | — | — | CN | disclosed |
| WO-2024091977-A1 | PROTECTION OF SENSITIVE SURFACES IN SEMICONDUCTOR PROCESSING | LAM RESEARCH CORPORATION (US) | 2024-05-02 | — | — | WO | disclosed |
| CN-111065966-B | Improved fill material for reducing pattern collapse | 霍尼韦尔国际公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-111133557-B | Thermally removable filler material for anti-stiction applications | 霍尼韦尔国际公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2004036264-A2 | POLYMERS, METHODS OF USE THEREOF, AND METHODS OF DECOMPOSITION THEREOF | GEORGIA TECH RESEARCH CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |
| US-6432891-B1 | INTRODUCING INTO SOLID OR LIQUID, SOAP OR DETERGENT COMPOUND SELECTED FROM 1-CYCLOHEXYL-ETHYLBUTYRATE, 1-CYCLOHEXYL-ETHYLACETATE, 1-CYCLOHEXYL-ETHANOL, 4-ISOPROPYL-CYCLOHEXYLPROPIONATE | BUSH BOAKE ALLEN INC., | 2002-08-13 | — | — | US | disclosed |
| US-20020032131-A1 | Malodor counteractant compositions and methods for preparing and using same | BUSH BOAKE ALLEN INC. | 2002-03-14 | — | — | US | disclosed |
| EP-1167507-A2 | Malodor counteractant compositions and methods for preparing and using same | Bush Boake Allen Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| EP-0251370-B1 | Cyclohexane-, cyclohexene- and cyclohexadiene, bicyclo[2.2.1]heptane and bicyclo [2.2.1]heptenecarboxylic acid esters, and also perfume compositions and perfumed products which contain one or more of said compounds as perfume component | NAARDEN INTERNATIONAL N.V. (NL) | 1989-10-25 | — | — | EP | disclosed |
| EP-0251370-A1 | Cyclohexane-, cyclohexene- and cyclohexadiene, bicyclo[2.2.1]heptane and bicyclo [2.2.1]heptenecarboxylic acid esters, and also perfume compositions and perfumed products which contain one or more of said compounds as perfume component | NAARDEN INTERNATIONAL N.V. (NL) | 1988-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260033306-A1 | PROTECTION OF SENSITIVE SURFACES IN SEMICONDUCTOR PROCESSING | CAPG, C9, CPSF1 | POLB 1194/4885TDP1 1042/4885APEX1 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.