SCHEMBL4270216

SCHEMBL4270216

CC(C)c1nc2c(c(C(F)(F)F)n1)CCN(C(=O)O)C2

nearest known ligand 0.39

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1261796 0.84 PARP1 (0.46) DPP4
SCHEMBL4266981 0.83 P2RX7 (0.45) DPP4
SCHEMBL4274835 0.81 DPP4 (0.51) DPP4
SCHEMBL4268225 0.81 DPP4 (0.52) DPP4
SCHEMBL21003124 0.80 P2RX7 (0.35)
SCHEMBL4263578 0.79 DPP4 (0.47) DPP4
SCHEMBL21003256 0.78 PDE10A (0.39)
SCHEMBL4551449 0.78 DPP4 (0.42) DPP4
SCHEMBL3390793 0.77 DPP4 (0.56) DPP4
SCHEMBL4265468 0.74 DPP4 (0.57) DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1863812-A4 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT LG LIFE SCIENCES LTD (KR) 2009-06-24 EP disclosed
EP-1863812-A1 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT LG Life Sciences Ltd. (KR) 2007-12-12 EP disclosed
WO-2006104356-A1 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT LG LIFE SCIENCES, LTD. (KR) 2006-10-05 WO disclosed