SCHEMBL15048810

SCHEMBL15048810

CCOc1cc(F)ccc1C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.51
HSD17B10 Q99714 1/20 0.51
KDM4E B2RXH2 2/20 0.49
CYP3A4 P08684 1/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
GAA P10253 1/20 0.47
LMNA P02545 1/20 0.47
GLA P06280 1/20 0.46
FFAR4 Q5NUL3 1/20 0.46
KEAP1 Q14145 1/20 0.44
MRGPRX1 Q96LB2 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
TDP1 Q9NUW8 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
MRGPRX4 Q96LA9 1/20 0.43
WDR5 P61964 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6505249 0.87 ADRB1 (0.52) TSHRHSD17B10KDM4EL3MBTL1MEN1
SCHEMBL1188345 0.86 TSHR (0.56) TSHRHSD17B10KDM4EL3MBTL1GAA
SCHEMBL31078354 0.86 TSHR (0.56) TSHRHSD17B10KDM4EL3MBTL1GAA
SCHEMBL30628273 0.86 CYP3A4 (0.61) TSHRKDM4ECYP3A4L3MBTL1LMNA
SCHEMBL4271221 0.86 CYP3A4 (0.61) TSHRKDM4ECYP3A4L3MBTL1LMNA
SCHEMBL28826108 0.84 KEAP1 (0.46) HSD17B10KDM4EFFAR4KEAP1KMT2A
SCHEMBL20471860 0.84 PTPN11 (0.52) TSHRCYP3A4LMNAMEN1KMT2A
SCHEMBL1546433 0.83 TSHR (0.54) TSHRHSD17B10KDM4ECYP3A4GAA
Hydrochloric Acid SCHEMBL30779134 0.83 MKNK1 (0.52) TSHRKDM4ECYP3A4L3MBTL1LMNA
SCHEMBL25794823 0.83 TDP1 (0.62) TSHRHSD17B10KDM4ECYP3A4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2025-07-03 US disclosed
US-20250170100-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF ANXIETY AND RELATED CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-20250170101-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF PAIN AND RELATED CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-12286421-B2 Inhibiting monoacylglycerol lipase (MAGL) PSY THERAPEUTICS, INC. (US) 2025-04-29 US disclosed
US-20250084065-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2025-03-13 US disclosed
WO-2025010394-A2 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF INFLAMMATORY CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-01-09 WO disclosed
WO-2025010392-A2 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISORDERS PSY THERAPEUTICS, INC. (US) 2025-01-09 WO disclosed
EP-4457213-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) Psy Therapeutics, Inc. (US) 2024-11-06 EP disclosed
US-20240360085-A1 Glucose Uptake Inhibitors KADMON CORPORATION, LLC (US) 2024-10-31 US disclosed
WO-2024215863-A2 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2024-10-17 WO disclosed
EP-2794608-B1 TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS MERCK PATENT GMBH (DE) 2016-09-14 EP disclosed
US-9403835-B2 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators ARES TRADING S.A. (CH) 2016-08-02 US disclosed
US-9403835-B2 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators ARES TRADING S.A. (CH) 2016-08-02 US disclosed
US-9403835-B2 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators ARES TRADING S.A. (CH) 2016-08-02 US disclosed
EP-2794608-A1 TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS Merck Patent GmbH (DE) 2014-10-29 EP disclosed
EP-2674434-A1 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators ARES TRADING S.A. (CH) 2013-12-18 EP disclosed
WO-2013091773-A1 TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS MERCK PATENT GMBH (DE) 2013-06-27 WO disclosed
WO-2013091773-A1 TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS MERCK PATENT GMBH (DE) 2013-06-27 WO disclosed
EP-2607364-A1 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators Ares Trading S.A. (CH) 2013-06-26 EP disclosed
EP-2607364-A1 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators Ares Trading S.A. (CH) 2013-06-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LIPC TSHR 3929/4885HSD17B10 301/4885KDM4E 2578/4885
US-20250084065-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LPL TSHR 4535/4885HSD17B10 81/4885KDM4E 1086/4885
US-12286421-B2 Inhibiting monoacylglycerol lipase (MAGL) MGLL, PNLIP, LIPC TSHR 3929/4885HSD17B10 301/4885KDM4E 2578/4885
US-20250170101-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF PAIN AND RELATED CONDITIONS MGLL, PNLIP, LIPA TSHR 4339/4885HSD17B10 505/4885KDM4E 1457/4885
US-20240360085-A1 Glucose Uptake Inhibitors SLC2A3, SLC2A1, SLC2A4 TSHR 2854/4885HSD17B10 806/4885KDM4E 2173/4885
US-20250170100-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF ANXIETY AND RELATED CONDITIONS MGLL, PNLIP, LIPA TSHR 2042/4885HSD17B10 248/4885KDM4E 2629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.