Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30610021 | 0.85 | TOP1 (0.56) | TOP1KMT2AMEN1CA1CA2 | |
| SCHEMBL382674 | 0.85 | TOP1 (0.56) | TOP1KMT2AMEN1CA1CA2 | |
| SCHEMBL3417492 | 0.74 | EGFR (0.76) | TOP1KMT2AMEN1CA1CA2 | |
| SCHEMBL11106693 | 0.74 | TDP1 (0.56) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL28575370 | 0.74 | MEN1 (0.72) | TOP1KMT2AMEN1CA1CA2 | |
| SCHEMBL13239956 | 0.73 | ALDH1A1 (0.58) | TOP1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8947495 | 0.72 | EGFR (0.73) | TOP1KMT2AMEN1CA1CA2 | |
| SCHEMBL3273673 | 0.71 | KMT2A (0.50) | TOP1KMT2AMEN1CA1CA2 | |
| SCHEMBL31435387 | 0.71 | MAPT (0.70) | TOP1KMT2AMEN1CA1CA2 | |
| SCHEMBL7792566 | 0.71 | EGFR (0.71) | TOP1KMT2AMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1081 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131032-A1 | NEUROTHERAPEUTIC TREATMENT FOR SEXUAL DYSFUNCTION | REVAAX PHARMACEUTICALS, LLC (US) | 2013-05-23 | — | — | US | claimed |
| US-7355040-B2 | Process for the preparation of cephalosporin compounds and synthetic intermediates | ZOETIS SERVICES LLC | 2008-04-08 | — | — | US | claimed |
| EP-0725783-B1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-12-18 | — | — | EP | claimed |
| EP-0915843-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSES | SMITHKLINE BEECHAM PLC (GB) | 1999-05-19 | — | — | EP | claimed |
| WO-1997041098-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | claimed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | claimed |
| EP-0321186-B1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1994-03-02 | — | — | EP | claimed |
| US-4923856-A | Penem compounds | BEECHAM GROUP P.L.C. (GB) | 1990-05-08 | — | — | US | claimed |
| EP-0321186-A1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | claimed |
| US-4798828-A | LACTAMASE INHIBITORS | BEECHAM GROUP P.L.C. (GB) | 1989-01-17 | — | — | US | claimed |
| US-4454069-A | Clavulanic acid salts and their preparation from the tertiary butyl amine salt | BEECHAM GROUP LIMITED (GB) | 1984-06-12 | — | — | US | claimed |
| US-4444754-A | SYNERGISTIC WITH PENICILLIN | BEECHAM GROUP LIMITED (GB) | 1984-04-24 | — | — | US | claimed |
| EP-0104010-A1 | Intermediates for clavulanic-acid derivatives | BEECHAM GROUP PLC (GB) | 1984-03-28 | — | — | EP | claimed |
| US-4426389-A | BACTERICIDES, ENZYME INHIBITORS | BEECHAM GROUP LIMITED (GB) | 1984-01-17 | — | — | US | claimed |
| US-4421760-A | β-Lactam antibiotic, its preparation and use | BEECHAM GROUP LIMITED (GB) | 1983-12-20 | — | — | US | claimed |
| US-4407815-A | AMINO ACID DERIVATIVE ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1983-10-04 | — | — | US | claimed |
| US-4372962-A | OXAPENICILLIN ANTIBIOTICS, BACTERICIDES, BETA-LACTAMASE INHIBITORS | BEECHAM GROUP LIMITED (GB) | 1983-02-08 | — | — | US | claimed |
| US-4359473-A | α-Amino deoxy clavulanic acid antibacterial agents | BEECHAM GROUP LIMITED (GB) | 1982-11-16 | — | — | US | claimed |
| US-4343807-A | BETA-LACTAMASE INHIBITORS, BACTERICIDES, ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1982-08-10 | — | — | US | claimed |
| US-4301168-A | BACTERICIDES, BETA-LACTAMASE INHIBITORS | BEECHAM GROUP LIMITED (GB) | 1981-11-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131032-A1 | NEUROTHERAPEUTIC TREATMENT FOR SEXUAL DYSFUNCTION | PREP, DNPEP, PRSS12 | TOP1 2640/4885KMT2A 4361/4885MEN1 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.