Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663 | 0.80 | CYP4F2 (0.51) | CYP4F2CYP4A11ALDH1A1HRH3SYK | |
| SCHEMBL7874 | 0.78 | CYP4F2 (0.43) | CYP4F2CYP4A11ALDH1A1HRH3FFAR4 | |
| SCHEMBL4097 | 0.78 | CYP4F2 (0.49) | CYP4F2CYP4A11ALDH1A1HRH3SYK | |
| SCHEMBL6779 | 0.77 | LPAR1 (0.42) | CYP4F2CYP4A11ALDH1A1HRH3FFAR4 | |
| SCHEMBL18597925 | 0.77 | LPAR1 (0.43) | CYP4F2CYP4A11ALDH1A1HRH3FFAR4 | |
| SCHEMBL4272 | 0.77 | CYP4F2 (0.45) | CYP4F2CYP4A11ALDH1A1HRH3SYK | |
| SCHEMBL7741 | 0.75 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1HRH3FFAR4 | |
| SCHEMBL5585 | 0.72 | LPAR1 (0.47) | CYP4F2CYP4A11HRH3SYKCYP4Z1 | |
| SCHEMBL6778 | 0.71 | ALOX5 (0.42) | CYP4F2CYP4A11ALDH1A1HRH3MGLL | |
| SCHEMBL1555 | 0.71 | HTT (0.45) | ALDH1A1PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |