Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6707 | 0.91 | LPAR1 (0.41) | TDP1L3MBTL1LPAR1LPAR2LPAR3 | |
| SCHEMBL7577 | 0.90 | FFAR1 (0.43) | LPAR1LPAR2LPAR3FFAR4 | |
| SCHEMBL7428 | 0.88 | EPHX1 (0.40) | TDP1ALDH1A1FFAR4HPGD | |
| SCHEMBL18597925 | 0.84 | LPAR1 (0.43) | CYP4F2CYP4A11TDP1MGLLL3MBTL1 | |
| SCHEMBL7874 | 0.84 | CYP4F2 (0.43) | CYP4F2CYP4A11TDP1MGLLL3MBTL1 | |
| SCHEMBL7722 | 0.84 | LPAR1 (0.48) | L3MBTL1LPAR1LPAR2LPAR3ALDH1A1 | |
| SCHEMBL1233 | 0.81 | CYP2C9 (0.42) | TDP1LPAR1ALDH1A1KDM4E | |
| SCHEMBL2337 | 0.81 | CYP2C9 (0.42) | TDP1LPAR1ALDH1A1KDM4E | |
| SCHEMBL6779 | 0.80 | LPAR1 (0.42) | CYP4F2CYP4A11MGLLL3MBTL1LPAR1 | |
| SCHEMBL7740 | 0.80 | LPAR1 (0.40) | CYP4F2CYP4A11TDP1MGLLLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |