Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269605 | 0.85 | KCNH2 (0.45) | KCNH2PI4KB | |
| SCHEMBL5775818 | 0.83 | MAP4K4 (0.45) | KCNH2PI4KBKDM4EALDH1A1MAPK1 | |
| SCHEMBL4271556 | 0.78 | ATM (0.45) | KCNH2 | |
| SCHEMBL5927867 | 0.77 | KCNH2 (0.46) | KCNH2 | |
| SCHEMBL5927248 | 0.75 | KCNH2 (0.39) | KCNH2PI4KBKDM4EALDH1A1HCAR2 | |
| SCHEMBL5927691 | 0.75 | KCNH2 (0.39) | KCNH2PI4KBTRPV1KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL5726214 | 0.75 | SLC2A1 (0.46) | KCNH2KDM4EALDH1A1 | |
| SCHEMBL5444742 | 0.74 | KCNH2 (0.44) | KCNH2PI4KB | |
| SCHEMBL591768 | 0.74 | KDM4E (0.51) | KCNH2KDM4EALDH1A1TSHRMAPK1 | |
| SCHEMBL4512584 | 0.74 | KCNH2 (0.45) | KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534793-B2 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2009-05-19 | — | — | US | disclosed |
| EP-1305308-B1 | AMINOPIPERIDINE QUINOLINES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2006-12-20 | — | — | EP | disclosed |
| US-20060079546-A1 | Aminopiperidine derivatives as antibacterials | SMITHKLINE BEECHAM P.L.C. | 2006-04-13 | — | — | US | disclosed |
| US-7001913-B1 | Aminopiperidine derivatives as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-02-21 | — | — | US | disclosed |
| US-20060014749-A1 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity | SMITHKLINE BEECHAM P.L.C. | 2006-01-19 | — | — | US | disclosed |
| US-6962917-B2 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-11-08 | — | — | US | disclosed |
| EP-1214314-B1 | AMINOPIPERIDINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2005-09-07 | — | — | EP | disclosed |
| US-20040038998-A1 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-02-26 | — | — | US | disclosed |
| EP-1214314-A2 | AMINOPIPERIDINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001007432-A2 | AMINOPIPERIDINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079546-A1 | Aminopiperidine derivatives as antibacterials | NPEPPS, AMPD2, DNPEP | KCNH2 1451/4885PI4KB 4012/4885TRPV1 1853/4885 |
| US-20040038998-A1 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity | AZI2, AMPD2, AMPD1 | KCNH2 1010/4885PI4KB 3318/4885TRPV1 2558/4885 |
| US-20060014749-A1 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity | AZI2, NPEPPS, AMPD2 | KCNH2 785/4885PI4KB 3594/4885TRPV1 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.