Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 2/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128911 | 0.80 | MAPK1 (0.57) | MAPK1KDM4EL3MBTL1ATMALDH1A1 | |
| SCHEMBL26145810 | 0.78 | MAPK1 (0.37) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| SCHEMBL27892719 | 0.78 | HDAC1 (0.55) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| SCHEMBL2642000 | 0.77 | CYP2C9 (0.53) | MAPK1ATMALDH1A1RAB9AMAPT | |
| SCHEMBL25659553 | 0.75 | CA12 (0.40) | MAPK1ALDH1A1NFKB1NFKB2RELA | |
| SCHEMBL4123825 | 0.75 | NAPRT (0.40) | MAPK1KDM4EHDAC1HDAC6SMYD3 | |
| SCHEMBL20267759 | 0.72 | LMNA (0.55) | MAPK1KDM4EL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL2175856 | 0.72 | KCNJ1 (0.39) | MAPK1KDM4EL3MBTL1HDAC1HDAC6 | |
| SCHEMBL185619 | 0.72 | ALDH1A1 (0.58) | KDM4ENAPRTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL669121 | 0.72 | NNMT (0.52) | KDM4EL3MBTL1SMYD3NNMTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |