Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22582588 | 0.94 | LMNA (0.74) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL22582593 | 0.94 | LMNA (0.74) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL12479774 | 0.94 | LMNA (0.74) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL22582589 | 0.94 | LMNA (0.74) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL3595934 | 0.88 | KMT2A (0.78) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL3595931 | 0.88 | KMT2A (0.78) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL15249477 | 0.88 | KMT2A (0.78) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL7545873 | 0.88 | L3MBTL1 (0.65) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL16250460 | 0.88 | KMT2A (0.78) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A | |
| SCHEMBL1886766 | 0.88 | KMT2A (0.78) | L3MBTL1LMNAOPRK1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |