Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10790278 | 0.87 | THRA (0.50) | MTNR1AMTNR1BTHRATHRBPPARG | |
| SCHEMBL3868622 | 0.86 | THRA (0.56) | THRATHRBPPARGPPARA | |
| Ethylene Glycol SCHEMBL11870625 | 0.84 | THRA (0.55) | THRATHRBPPARGPPARA | |
| SCHEMBL23069656 | 0.84 | THRA (0.58) | THRATHRBPPARGPPARA | |
| SCHEMBL27509209 | 0.84 | THRA (0.58) | THRATHRBPPARGPPARA | |
| SCHEMBL4275191 | 0.83 | PPARG (0.51) | MTNR1AMTNR1BTHRATHRBPPARG | |
| SCHEMBL10359207 | 0.83 | THRA (0.57) | THRATHRBPPARGPPARA | |
| SCHEMBL31493123 | 0.83 | THRA (0.57) | THRATHRBPPARGPPARA | |
| SCHEMBL8619436 | 0.81 | L3MBTL1 (0.46) | MTNR1AMTNR1B | |
| SCHEMBL4266854 | 0.80 | KDM4E (0.37) | MTNR1AMTNR1BTHRATHRBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |