Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21616685 | 0.96 | RIPK1 (0.65) | RIPK1HSD11B1HSP90AA1HSP90AB1EPHX2 | |
| SCHEMBL24365782 | 0.86 | RIPK1 (0.63) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| SCHEMBL17114341 | 0.86 | RIPK1 (0.63) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| SCHEMBL7469150 | 0.86 | RIPK1 (0.63) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| SCHEMBL30281143 | 0.84 | RIPK1 (0.62) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| Water SCHEMBL27902502 | 0.84 | RIPK1 (0.62) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| SCHEMBL12184218 | 0.82 | RIPK1 (0.58) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| SCHEMBL28171621 | 0.82 | RIPK1 (0.67) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| SCHEMBL27672000 | 0.82 | RIPK1 (0.58) | RIPK1HSD11B1PRMT5WDR77PARP14 | |
| SCHEMBL27830000 | 0.82 | RIPK1 (0.59) | RIPK1HSD11B1PRMT5WDR77PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009072643-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-11 | — | — | WO | disclosed |