Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848686 | 0.88 | BACE1 (0.40) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4282729 | 0.86 | KMT2A (0.41) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4282044 | 0.81 | NPC1 (0.48) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4277820 | 0.78 | KMT2A (0.40) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4277770 | 0.76 | KMT2A (0.47) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4552596 | 0.75 | TSHR (0.46) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4280778 | 0.75 | KMT2A (0.45) | KMT2AMAPTALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL1852252 | 0.74 | BACE1 (0.45) | KMT2AMAPTALDH1A1MEN1GPR119 | |
| SCHEMBL4282720 | 0.73 | GPR119 (0.45) | KMT2AMEN1GPR119RAB9AHPGD | |
| SCHEMBL4284695 | 0.73 | GPR119 (0.44) | ALDH1A1SMN1; SMN2GPR119TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |