Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284695 | 0.89 | GPR119 (0.44) | GPR119PIK3CDTLR9TLR8TLR7 | |
| SCHEMBL1853083 | 0.81 | GPR119 (0.52) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL27415464 | 0.79 | KDM4E (0.46) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL19460883 | 0.77 | GPR119 (0.51) | GPR119TLR9TLR8TLR7LNPEP | |
| SCHEMBL4552480 | 0.76 | KDM4E (0.44) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL1850724 | 0.72 | GPR119 (0.52) | GPR119MEN1HPGDKMT2ACACNB4 | |
| SCHEMBL4308215 | 0.72 | GPR119 (0.46) | GPR119MEN1KMT2APIK3CDTLR9 | |
| SCHEMBL9987440 | 0.71 | GPR119 (0.45) | GPR119PIK3CD | |
| SCHEMBL26926850 | 0.70 | CACNB4 (0.51) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3657261 | 0.70 | RAB9A (0.48) | GPR119MEN1HPGDKMT2ATLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |