SCHEMBL4278972

SCHEMBL4278972

CC(=O)OC[C@H]1O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1OC(C)=O

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.61
TK1 P04183 6/20 0.54
ABCG2 Q9UNQ0 3/20 0.54
ABCB1 P08183 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11986879 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL2327879 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL31227958 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL32668971 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL13948025 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL1827369 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL4278968 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL12969271 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL22143532 1.00 RNASE1 (0.61) RNASE1TK1ABCG2ABCB1
SCHEMBL4495987 0.94 RNASE1 (0.64) RNASE1TK1ABCG2ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1466004-A1 PROCESS FOR THE SELECTIVE ENZYMATIC HYDROLYSIS OF NUCLEOSIDE POLYESTERS Innovate Biotechnology S.R.L. (IT) 2004-10-13 EP claimed
WO-2003057894-A1 PROCESS FOR THE SELECTIVE ENZYMATIC HYDROLYSIS OF NUCLEOSIDE POLYESTERS INNOVATE BIOTECHNOLOGY S.R.L. (IT) 2003-07-17 WO claimed
WO-2024186176-A1 METHOD FOR PREPARING MODIFIED NUCLEOSIDES FROM THYMIDINE 주식회사 압타머사이언스 2024-09-12 WO disclosed
US-8877734-B2 Seleny-methyluracil compounds, radiosensitizer and pharmaceutical composition using them KONGJU NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2014-11-04 US disclosed
US-20140065676-A1 STACKING NUCLEIC ACID AND METHODS FOR USE THEREOF QUANTIBACT A/S (DK) 2014-03-06 US disclosed
US-20130211067-A1 NOVEL SELENY-METHYLURACIL COMPOUNDS, RADIOSENSITIZER AND PHARMACEUTICAL COMPOSITION USING THEM KONGJU NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2013-08-15 US disclosed
WO-2012050264-A1 NOVEL SELENY-METHYLURACIL COMPOUNDS, RADIOSENSITIZER AND PHARMACEUTICAL COMPOSITION USING THEM KONGJU NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2012-04-19 WO disclosed
US-20090105186-A1 Beta-L-N4-Hydroxycytosine Deoxynucleosides and their use as Pharmaceutical Agents in the Prophylaxis or Therapy of Viral Diseases MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN (DE) 2009-04-23 US disclosed
US-7169765-B1 Acyl deoxyribonucleoside derivatives and uses thereof WELLSTAT THERAPEUTICS CORPORATION (US) 2007-01-30 US disclosed
US-20060217345-A1 Beta-L-nucleosides and use thereof as pharmaceutical agents for the treatment of viral diseases MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) 2006-09-28 US disclosed
EP-1466004-A1 PROCESS FOR THE SELECTIVE ENZYMATIC HYDROLYSIS OF NUCLEOSIDE POLYESTERS Innovate Biotechnology S.R.L. (IT) 2004-10-13 EP disclosed
US-6297222-B1 TREATING OR PREVENTING RADIATION, MUTAGEN AND SUNLIGHT-INDUCED BIOLOGICAL DAMAGE, AND METHODS FOR IMPROVING WOUND HEALING AND TISSUE REPAIR PRO-NEURON, INC. 2001-10-02 US disclosed
US-6103701-A ADMINISTERING COMPOSITIONS COMPRISING ACYL DERIVATIVES OF 2'-DEOXYRIBONUCLEOSIDES; FOR IMPROVING WOUND HEALING AND TISSUE REPAIR VON BORSTEL REID WARREN (US) 2000-08-15 US disclosed
US-6020322-A Acyl deoxyribonucleoside derivatives and uses thereof PRO-NEURON, INC. (US) 2000-02-01 US disclosed
EP-0683171-B1 A process for the preparation of beta-thymidine COUNCIL SCIENT IND RES (IN) 1998-12-23 EP disclosed
US-5596087-A Process for the preparation of beta thymidine COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 1997-01-21 US disclosed
EP-0355131-B1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO NEURON INC (US) 1996-09-04 EP disclosed
EP-0712629-A1 Acyl deoxyribonucleoside derivatives and uses thereof PRO-NEURON, INC. (US) 1996-05-22 EP disclosed
EP-0683171-A1 A process for the preparation of beta-thymidine Council of Scientific and Industrial Research (IN) 1995-11-22 EP disclosed
EP-0355131-A1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO-NEURON, INC. (US) 1990-02-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130211067-A1 NOVEL SELENY-METHYLURACIL COMPOUNDS, RADIOSENSITIZER AND PHARMACEUTICAL COMPOSITION USING THEM SCLY, SELENOI, MGMT RNASE1 851/4885TK1 2253/4885ABCG2 565/4885
US-20090105186-A1 Beta-L-N4-Hydroxycytosine Deoxynucleosides and their use as Pharmaceutical Agents in the Prophylaxis or Therapy of Viral Diseases TYMP, ENTPD5, NUDT1 RNASE1 224/4885TK1 102/4885ABCG2 1631/4885
US-20060217345-A1 Beta-L-nucleosides and use thereof as pharmaceutical agents for the treatment of viral diseases NTPCR, PNP, TYMP RNASE1 62/4885TK1 11/4885ABCG2 509/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.