Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285208 | 0.82 | PARP1 (0.41) | KDM4EKMT2ANPC1ALDH1A1POLB | |
| SCHEMBL1521812 | 0.78 | KIT (0.40) | TRPV1MAPTMAPK14MAPK13MAPK12 | |
| SCHEMBL4276058 | 0.70 | BRAF (0.45) | MAPK14MAPK13ALDH1A1NTRK1 | |
| SCHEMBL1521657 | 0.68 | TRPV1 (0.42) | TRPV1MAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL1521602 | 0.68 | TRPV1 (0.40) | TRPV1MAPTKDM4EALDH1A1KIT | |
| SCHEMBL5065406 | 0.64 | BRAF (0.68) | KITPDGFRASRC | |
| SCHEMBL1521574 | 0.64 | MAPK14 (0.41) | MAPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1521548 | 0.64 | MAPK14 (0.43) | MAPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL20861817 | 0.64 | KMT2A (0.76) | MAPTKDM4EMEN1KMT2ANPC1 | |
| SCHEMBL1522039 | 0.64 | FGFR4 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | claimed |