Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563487 | 0.88 | PARP1 (0.40) | PARP1NPC1RAB9AKMT2AEPHX2 | |
| SCHEMBL1521987 | 0.78 | FGFR1 (0.43) | PARP1NPC1RAB9AKMT2AEPHX2 | |
| SCHEMBL1521947 | 0.76 | RAB9A (0.41) | PARP1NPC1RAB9AKMT2AEPHX2 | |
| SCHEMBL29894322 | 0.75 | NPC1 (0.40) | PARP1NPC1RAB9AKMT2AEPHX2 | |
| SCHEMBL1521769 | 0.75 | NPC1 (0.40) | PARP1NPC1RAB9AKMT2AEPHX2 | |
| SCHEMBL1522057 | 0.74 | NPC1 (0.39) | PARP1NPC1RAB9AKMT2AEPHX2 | |
| SCHEMBL1521676 | 0.74 | PARP1 (0.38) | PARP1NPC1RAB9AKMT2AEPHX2 | |
| SCHEMBL4284971 | 0.70 | KDR (0.42) | EPHX2 | |
| SCHEMBL4277338 | 0.70 | BRAF (0.47) | ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4277743 | 0.70 | KDR (0.41) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | claimed |