Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961836 | 0.86 | KEAP1 (0.68) | KEAP1NFE2L2GLAPPARGTAS2R14 | |
| SCHEMBL1082207 | 0.86 | GLA (0.69) | KEAP1NFE2L2GLATAS2R14CNR2 | |
| SCHEMBL21595413 | 0.84 | GLA (0.51) | KEAP1NFE2L2GLATAS2R14L3MBTL1 | |
| SCHEMBL8607609 | 0.83 | KEAP1 (0.64) | KEAP1NFE2L2GLAPPARGTAS2R14 | |
| SCHEMBL9972493 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2GLAPPARGTAS2R14 | |
| SCHEMBL8200276 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2GLAPPARGTAS2R14 | |
| SCHEMBL8606028 | 0.79 | CA9 (0.60) | KEAP1NFE2L2GLAPPARGTAS2R14 | |
| SCHEMBL5190476 | 0.79 | TAS2R14 (0.63) | KEAP1NFE2L2GLAPPARGTAS2R14 | |
| SCHEMBL8607106 | 0.78 | KEAP1 (0.57) | KEAP1NFE2L2GLAPPARGTAS2R14 | |
| SCHEMBL21753821 | 0.78 | GLA (0.54) | GLACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153569-A2 | CB1 RECEPTOR MODULATORS | 7TM PHARMA A/S (DK) | 2009-12-23 | — | — | WO | disclosed |