Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.36 |
| ▸ | ITGAL | P20701 | 3/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281911 | 1.00 | NPC1 (0.38) | NPC1L3MBTL1ITGB2ICAM1ITGAL | |
| SCHEMBL4277195 | 0.84 | NPC1 (0.41) | NPC1L3MBTL1ITGB2ICAM1ITGAL | |
| SCHEMBL4277188 | 0.84 | NPC1 (0.41) | NPC1L3MBTL1ITGB2ICAM1ITGAL | |
| SCHEMBL4277854 | 0.84 | PTGES (0.45) | ITGB2ICAM1ITGALMEN1ALDH1A1 | |
| SCHEMBL4277853 | 0.84 | PTGES (0.45) | ITGB2ICAM1ITGALMEN1ALDH1A1 | |
| SCHEMBL4286150 | 0.81 | ALDH1A1 (0.41) | NPC1L3MBTL1ITGALMEN1ALDH1A1 | |
| SCHEMBL4286153 | 0.81 | ALDH1A1 (0.41) | NPC1L3MBTL1ITGALMEN1ALDH1A1 | |
| SCHEMBL13879620 | 0.79 | ITGB2 (0.48) | L3MBTL1ITGB2ICAM1ITGALMAPK1 | |
| SCHEMBL4280122 | 0.78 | GAA (0.44) | NPC1L3MBTL1ITGB2ICAM1ITGAL | |
| SCHEMBL13879626 | 0.78 | LMNA (0.41) | ITGB2ICAM1ITGALMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | EIF2AK2, HAVCR2, RTF2 | NPC1 680/4885L3MBTL1 1550/4885ITGB2 4487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.