Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227362 | 0.83 | POLB (1.00) | POLBATMALDH1A1HTTL3MBTL1 | |
| SCHEMBL6015071 | 0.83 | NPC1 (0.60) | POLBMAPTHTTGAA | |
| SCHEMBL1221514 | 0.83 | POLB (0.60) | POLBLMNAALDH1A1GAA | |
| SCHEMBL14046661 | 0.82 | POLB (0.73) | POLBLMNASTAT3USP2PAK1 | |
| SCHEMBL7440948 | 0.81 | POLB (0.71) | POLBLMNASTAT3USP2PAK1 | |
| SCHEMBL654102 | 0.77 | ALDH1A1 (0.76) | POLBLMNAUSP2ALDH1A1MAPT | |
| SCHEMBL1777934 | 0.77 | ALDH1A1 (0.57) | POLBLMNAUSP2ALDH1A1ALOX15 | |
| Piperazine SCHEMBL11871903 | 0.76 | ALDH1A1 (0.48) | POLBLMNAATMALDH1A1MAPT | |
| SCHEMBL10837199 | 0.76 | ATM (0.76) | POLBLMNAATMALDH1A1CYP2D6 | |
| SCHEMBL698365 | 0.75 | NPC1 (0.71) | POLBLMNAALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318697-A1 | PROCESS FOR PREPARING A PIPERAZINE DERIVATIVE | MEDICHEM, S.A. (ES) | 2009-12-24 | — | — | US | claimed |
| US-20090318697-A1 | PROCESS FOR PREPARING A PIPERAZINE DERIVATIVE | MEDICHEM, S.A. (ES) | 2009-12-24 | — | — | US | disclosed |
| US-20090318697-A1 | PROCESS FOR PREPARING A PIPERAZINE DERIVATIVE | MEDICHEM, S.A. (ES) | 2009-12-24 | — | — | US | disclosed |
| WO-2009153651-A1 | PROCESS FOR PREPARING A PIPERAZINE DERIVATIVE | MEDICHEM, S.A. (ES) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009153651-A1 | PROCESS FOR PREPARING A PIPERAZINE DERIVATIVE | MEDICHEM, S.A. (ES) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318697-A1 | PROCESS FOR PREPARING A PIPERAZINE DERIVATIVE | PTGER1, PTGER2, SCN5A | POLB 837/4885LMNA 1693/4885STAT3 4877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.