Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10459921 | 0.90 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1LMNAHTTGAA | |
| SCHEMBL11221733 | 0.82 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1LMNAHTTGAA | |
| SCHEMBL9782499 | 0.80 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1LMNAHTTGAA | |
| SCHEMBL7879085 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAHTTGAASMN1; SMN2 | |
| SCHEMBL4252275 | 0.79 | ALDH1A1 (0.48) | ALDH1A1LMNAGAAKDM4EPOLB | |
| Hydrochloric Acid SCHEMBL9621338 | 0.79 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1LMNAHTTGAA | |
| SCHEMBL9255037 | 0.78 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1LMNAHTTGAA | |
| SCHEMBL22172135 | 0.78 | ALDH1A1 (0.52) | ALDH1A1LMNAHTTGAAKDM4E | |
| SCHEMBL10447618 | 0.77 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1LMNAGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL15303081 | 0.76 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1LMNAHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197891-A1 | Use of (4-Alkylpiperazinyl)(phenyl) methanones in the treatment of alzheimer's disease | SAMARITAN PHARMACEUTICALS, INC. | 2009-08-06 | — | — | US | claimed |
| EP-1755605-A2 | USE OF (4-ALKYLPIPERAZINYL)(PHENYL) METHANONES IN THE TREATMENT OF ALZHEIMER'S DISEASE | Samaritan Pharmaceuticals, Inc. (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005108378-A2 | USE OF (4-ALKYLPIPERAZINYL) (PHENYL) METHANONES IN THE TREATMENT OF ALZHEIMER’S DISEASE | SAMARITAN PHARMACEUTICALS, INC. (US) | 2005-11-17 | — | — | WO | claimed |
| US-20090197891-A1 | Use of (4-Alkylpiperazinyl)(phenyl) methanones in the treatment of alzheimer's disease | SAMARITAN PHARMACEUTICALS, INC. | 2009-08-06 | — | — | US | disclosed |
| US-20090197891-A1 | Use of (4-Alkylpiperazinyl)(phenyl) methanones in the treatment of alzheimer's disease | SAMARITAN PHARMACEUTICALS, INC. | 2009-08-06 | — | — | US | disclosed |
| EP-1755605-A2 | USE OF (4-ALKYLPIPERAZINYL)(PHENYL) METHANONES IN THE TREATMENT OF ALZHEIMER'S DISEASE | Samaritan Pharmaceuticals, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005108378-A2 | USE OF (4-ALKYLPIPERAZINYL) (PHENYL) METHANONES IN THE TREATMENT OF ALZHEIMER’S DISEASE | SAMARITAN PHARMACEUTICALS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197891-A1 | Use of (4-Alkylpiperazinyl)(phenyl) methanones in the treatment of alzheimer's disease | APP, PSEN1, PSEN2 | ALDH1A1 1469/4885L3MBTL1 1640/4885LMNA 2275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.