Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4272358 | 0.79 | PTGDR2 (0.57) | PPARGPPARACYP4F2CYP4A11MMP13 | |
| SCHEMBL4267501 | 0.78 | PTGDR2 (0.55) | ALOX5PPARGPPARAPTGDR2 | |
| SCHEMBL4276035 | 0.77 | PTGDR2 (0.41) | PPARGPPARAMMP13PTGDR2 | |
| SCHEMBL3174515 | 0.72 | PTGDR2 (0.65) | ALOX5POLBCYP1A2SMN1; SMN2PTGDR2 | |
| SCHEMBL4425984 | 0.71 | CYP4F2 (0.64) | ALOX5PDE3BPDE3AP2RY12PPARG | |
| SCHEMBL19889918 | 0.70 | ALOX5 (0.57) | ALOX5PPARGPPARAMAPK1CYP4F2 | |
| SCHEMBL4281384 | 0.70 | PTGDR2 (0.39) | PPARGCYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL7622998 | 0.70 | CYP4F2 (0.51) | PPARGPPARACYP4F2CYP4A11TDP1 | |
| SCHEMBL3175607 | 0.69 | CYP4F2 (0.65) | ALOX5PDE3BPDE3AP2RY12PPARG | |
| SCHEMBL4276046 | 0.69 | PTGDR2 (0.41) | PDE3BPDE3AP2RY12CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |