Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quetiapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | HRH1 | P35367 | 2/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quetiapine SCHEMBL29360153 | 1.00 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL4638768 | 1.00 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL7932 | 1.00 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL392703 | 0.99 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL2155179 | 0.99 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL396057 | 0.99 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL1649418 | 0.99 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL27866344 | 0.98 | DRD2 (0.96) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL27907990 | 0.98 | DRD2 (0.96) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL2537668 | 0.97 | DRD2 (0.94) | DRD2ADRA2ALMNACHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275747-A1 | METHODS FOR THE PREPARATION OF SALTS OF 2-[2-(4-DIBENZO[B,F][1,4]THIAZEPIN-11-YL-1-PIPERAZINYL)ETHOXYL]ETHANOL (QUETIAPINE) AND FOR THE PURIFICATION THEREOF | FARMAK, A.S. (CZ) | 2009-11-05 | — | — | US | claimed |
| WO-2022002011-A1 | SALT OF 2-(SUBSTITUTED PYRIMIDINYL)THIAZOLECARBOXAMIDE COMPOUND, AND COMPOSITION AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2022-01-06 | — | — | WO | disclosed |
| WO-2016025494-A2 | METHODS OF MONITORING ADHERENCE TO QUETIAPINE THERAPY | AMERITOX, LTD. (US) | 2016-02-18 | — | — | WO | disclosed |
| EP-1951256-A1 | QUETIAPINE IN A CONTROLLED RELEASE FORMULATION | Astra Zeneca AB (SE) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007058593-A1 | QUETIAPINE IN A CONTROLLED RELEASE FORMULATION | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |