Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quetiapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.98 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.98 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.98 |
| ▸ | HTR1A | P08908 | 2/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.98 |
| ▸ | DRD1 | P21728 | 2/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.98 |
| ▸ | HRH1 | P35367 | 2/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.98 |
| ▸ | DRD3 | P35462 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quetiapine SCHEMBL396057 | 1.00 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL29360153 | 0.99 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL7932 | 0.99 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL4283801 | 0.99 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL4638768 | 0.99 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL392703 | 0.98 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL1649418 | 0.98 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL27907990 | 0.97 | DRD2 (0.96) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL27866344 | 0.97 | DRD2 (0.96) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL2537668 | 0.96 | DRD2 (0.94) | DRD2ADRA2ALMNACHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3476218-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2019-05-01 | — | — | EP | disclosed |
| EP-2544536-B1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM INC (US) | 2018-12-12 | — | — | EP | disclosed |
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| CN-107714703-A | The amino acid conjugate of Quetiapine, its preparation and application | 凯姆制药公司 | 2018-02-23 | — | — | CN | disclosed |
| US-9890150-B2 | Fatty acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9889198-B2 | Fatty acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| CN-104586859-B | The amino acid conjugate of Quetiapine, its preparation and application | 凯姆制药公司 | 2017-12-05 | — | — | CN | disclosed |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246301-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20130158007-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | KEMPHARM, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130045247-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM INC. | 2013-02-21 | — | — | US | disclosed |
| EP-2544536-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2013-01-16 | — | — | EP | disclosed |
| CN-102781236-A | Amino acid conjugates of quetiapine, methods of making and using the same | KEMPHARM INC | 2012-11-14 | — | — | CN | disclosed |
| EP-2519101-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2012-11-01 | — | — | US | disclosed |
| US-20110223207-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-09-15 | — | — | US | disclosed |
| WO-2011112657-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2011-09-15 | — | — | WO | disclosed |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-07-28 | — | — | US | disclosed |
| WO-2011082076-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246301-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | FASN, FADS1, FADS2 | DRD2 263/4885HTR2A 291/4885HTR2C 542/4885 |
| US-20130045247-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | FASN, FADS1, FADS2 | DRD2 263/4885HTR2A 291/4885HTR2C 542/4885 |
| US-20130158007-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | FASN, FADS1, FADS2 | DRD2 263/4885HTR2A 291/4885HTR2C 542/4885 |
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HTR2A 197/4885HTR2C 379/4885 |
| US-20110223207-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | FASN, FADS1, FADS2 | DRD2 263/4885HTR2A 291/4885HTR2C 542/4885 |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HTR2A 197/4885HTR2C 379/4885 |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 176/4885HTR2A 230/4885HTR2C 402/4885 |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | SLC1A5, QPCT, SLC6A15 | DRD2 152/4885HTR2A 210/4885HTR2C 357/4885 |
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HTR2A 197/4885HTR2C 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.