Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quetiapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.94 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.94 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.94 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.94 |
| ▸ | HTR1A | P08908 | 2/20 | 0.94 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.94 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.94 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.94 |
| ▸ | DRD1 | P21728 | 2/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.94 |
| ▸ | HRH1 | P35367 | 2/20 | 0.94 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.94 |
| ▸ | DRD3 | P35462 | 2/20 | 0.94 |
| ▸ | HTR2B | P41595 | 2/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.94 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quetiapine SCHEMBL27866344 | 0.97 | DRD2 (0.96) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL29360153 | 0.97 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL4638768 | 0.97 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL7932 | 0.97 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL4283801 | 0.97 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL396057 | 0.96 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL392703 | 0.96 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL1649418 | 0.96 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL2155179 | 0.96 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2HTR1A | |
| Quetiapine SCHEMBL27907990 | 0.95 | DRD2 (0.96) | DRD2ADRA2ALMNACHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044039-B2 | Quetiapine hemifumarate purification by crystallization | FERMION OY (FI) | 2011-10-25 | — | — | US | disclosed |
| US-20090156802-A1 | Quetiapine Hemifumarate Purification by Crystallization | FERMION OY (FI) | 2009-06-18 | — | — | US | disclosed |
| EP-1948628-A1 | QUETIAPINE HEMIFUMARATE PURIFICATION BY CRYSTALLIZATION | Fermion Oy (FI) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007048870-A1 | QUETIAPINE HEMIFUMARATE PURIFICATION BY CRYSTALLIZATION | FERMION OY (FI) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156802-A1 | Quetiapine Hemifumarate Purification by Crystallization | FH, FAH, FBP1 | DRD2 2716/4885HTR2A 2400/4885HTR2C 2780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.