SCHEMBL4283891

SCHEMBL4283891

COc1ccc(-c2c(O)cc(COC(C)=O)c(CO)c2OC)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 3/20 0.43
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
GLO1 Q04760 1/20 0.37
PDE4B Q07343 3/20 0.37
PDE4A P27815 2/20 0.37
PDE4C Q08493 2/20 0.37
PDE4D Q08499 2/20 0.37
MAPK1 P28482 2/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP3A4 P08684 1/20 0.37
HPGD P15428 1/20 0.37
PDE5A O76074 1/20 0.37
PDE1A P54750 1/20 0.37
PDE1B Q01064 1/20 0.37
PDE3B Q13370 1/20 0.37
PDE1C Q14123 1/20 0.37
PDE3A Q14432 1/20 0.37
HSP90AA1 P07900 2/20 0.36
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4285589 0.87 BACE1 (0.39) BACE1MEN1KMT2AGLO1MAPK1
SCHEMBL10603090 0.68 KDM4E (0.45) MAPK1ALDH1A1CYP3A4HPGDSMN1; SMN2
SCHEMBL19721780 0.67 ALDH1A1 (0.56) BACE1ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL10603089 0.67 ABCB11 (0.41) KMT2AALDH1A1CYP3A4HPGDTP53
SCHEMBL27955323 0.67 MAPT (0.46) MEN1KMT2AMAPK1ALDH1A1CYP3A4
SCHEMBL27835389 0.67 TDP1 (0.44) MAPK1ALDH1A1CYP3A4HPGDNPC1
SCHEMBL27739156 0.66 ALDH1A1 (0.50) BACE1MEN1KMT2APDE4BPDE4A
SCHEMBL1871228 0.65 ALDH1A1 (0.62) ALDH1A1NPC1RAB9ASMN1; SMN2POLB
SCHEMBL112518 0.65 ALDH1A1 (0.62) ALDH1A1NPC1RAB9ASMN1; SMN2POLB
SCHEMBL10732769 0.65 CYP1A2 (0.42) MAPK1ALDH1A1CYP3A4HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 BACE1 2726/4885MEN1 3776/4885KMT2A 1397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.