SCHEMBL4285589

SCHEMBL4285589

COc1ccc(-c2c(O)cc(COC(C)=O)c(CO)c2F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 3/20 0.39
GLO1 Q04760 1/20 0.39
HSP90AA1 P07900 2/20 0.38
POLB P06746 2/20 0.38
GAA P10253 3/20 0.38
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
ALDH1A1 P00352 3/20 0.36
HPGD P15428 3/20 0.36
MAPK1 P28482 2/20 0.36
CYP3A4 P08684 1/20 0.36
KDM4E B2RXH2 3/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPC1 O15118 2/20 0.36
TP53 P04637 2/20 0.36
CASP3 P42574 2/20 0.36
RAB9A P51151 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4283891 0.87 BACE1 (0.43) BACE1GLO1HSP90AA1POLBGAA
SCHEMBL13034125 0.69 MTNR1B (0.48) POLBALDH1A1HPGDMAPK1CYP3A4
SCHEMBL4285014 0.67 CYP3A4 (0.35) CYP3A4CYP2D6CYP2C9ESR1ESR2
SCHEMBL19721780 0.66 ALDH1A1 (0.56) BACE1POLBALDH1A1NPC1RAB9A
SCHEMBL4289242 0.66 CYP3A4 (0.47) HSP90AA1POLBMEN1KMT2AALDH1A1
SCHEMBL4291912 0.65 NFKB1 (0.42) HSP90AA1MEN1KMT2AALDH1A1HPGD
SCHEMBL4286675 0.65 CYP3A4 (0.37) ALDH1A1CYP3A4KDM4EMAPTHSD17B10
SCHEMBL4684224 0.65 MMP9 (0.43) MEN1KMT2AALDH1A1CYP3A4KDM4E
SCHEMBL112518 0.64 ALDH1A1 (0.62) POLBALDH1A1NPC1RAB9AMAPT
SCHEMBL1871228 0.64 ALDH1A1 (0.62) POLBALDH1A1NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 BACE1 2726/4885GLO1 810/4885HSP90AA1 1742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.