SCHEMBL4283897

SCHEMBL4283897

COc1ccc(C(=O)c2c(O)cc(C)cc2Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.54
MAPT P10636 3/20 0.52
RAB9A P51151 2/20 0.52
KMT2A Q03164 3/20 0.51
MAPK1 P28482 3/20 0.50
LMNA P02545 2/20 0.50
MEN1 O00255 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
RXFP1 Q9HBX9 1/20 0.50
ALDH1A1 P00352 2/20 0.48
RAF1 P04049 1/20 0.48
GFER P55789 1/20 0.48
PAX8 Q06710 1/20 0.48
GAA P10253 3/20 0.47
POLB P06746 2/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
PARP1 P09874 1/20 0.46
PARP10 Q53GL7 1/20 0.46
PARP2 Q9UGN5 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4289278 0.84 MAPT (0.51) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL4293769 0.83 CYP3A4 (0.56) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL4285539 0.82 MAP4K4 (0.45) KMT2AMEN1RAF1PARP10
SCHEMBL4283203 0.82 MEN1 (0.47) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL4292221 0.82 MEN1 (0.54) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL4288308 0.81 HPGD (0.50) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL4285255 0.81 HPGD (0.50) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL23663333 0.80 MAPT (0.64) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL4284291 0.78 KMT2A (0.62) HPGDMAPTRAB9AKMT2AMAPK1
SCHEMBL4285302 0.77 HPGD (0.46) HPGDMAPTRAB9AKMT2AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 HPGD 2655/4885MAPT 2884/4885RAB9A 1308/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.