SCHEMBL4284291

SCHEMBL4284291

COc1ccc(C(=O)c2c(O)cccc2Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.62
HPGD P15428 3/20 0.57
MAPT P10636 4/20 0.51
RAB9A P51151 3/20 0.51
LMNA P02545 3/20 0.49
MAPK1 P28482 3/20 0.49
MEN1 O00255 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
ALDH1A1 P00352 3/20 0.48
NPC1 O15118 2/20 0.48
HTT P42858 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
MAOB P27338 1/20 0.48
ESR1 P03372 1/20 0.48
ESR2 Q92731 1/20 0.48
CES2 O00748 2/20 0.47
CES1 P23141 2/20 0.47
STS P08842 1/20 0.47
RAF1 P04049 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL533764 0.79 ALDH1A1 (0.50) KMT2AMAPTRAB9ALMNAMEN1
SCHEMBL4283897 0.78 HPGD (0.54) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL1443352 0.77 HPGD (0.61) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL11578249 0.77 KMT2A (1.00) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL5134949 0.75 KMT2A (0.59) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL11363230 0.75 RAB9A (0.68) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL11322571 0.75 KMT2A (0.72) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL1407588 0.75 KMT2A (0.72) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL4288308 0.75 HPGD (0.50) KMT2AHPGDMAPTRAB9ALMNA
SCHEMBL29722657 0.75 KMT2A (0.68) KMT2AHPGDMAPTRAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 KMT2A 1397/4885HPGD 2655/4885MAPT 2884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.