SCHEMBL4285255

SCHEMBL4285255

COc1ccc(C(=O)c2c(Cl)cc(C)cc2OC(C)=O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.50
MAPT P10636 6/20 0.49
RAB9A P51151 2/20 0.49
BACE1 P56817 1/20 0.49
KMT2A Q03164 5/20 0.48
ALDH1A1 P00352 2/20 0.47
GAA P10253 2/20 0.47
LMNA P02545 3/20 0.46
MAPK1 P28482 3/20 0.46
NPSR1 Q6W5P4 3/20 0.46
MEN1 O00255 2/20 0.46
RXFP1 Q9HBX9 1/20 0.46
NPC1 O15118 2/20 0.46
TUBB4A P04350 1/20 0.46
TUBB P07437 1/20 0.46
TUBA3C P0DPH7 1/20 0.46
TUBA1B P68363 1/20 0.46
TUBA4A P68366 1/20 0.46
TUBB4B P68371 1/20 0.46
TUBB3 Q13509 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4281349 0.87 KMT2A (0.57) HPGDMAPTRAB9ABACE1KMT2A
SCHEMBL4287208 0.86 BACE1 (0.49) HPGDMAPTRAB9ABACE1KMT2A
SCHEMBL4282990 0.85 MAPT (0.46) HPGDMAPTRAB9AKMT2AALDH1A1
SCHEMBL4282761 0.83 KMT2A (0.50) HPGDMAPTRAB9ABACE1KMT2A
SCHEMBL4282822 0.83 RORC (0.41) MAPTKMT2AMAPK1MEN1RAF1
SCHEMBL4283897 0.81 HPGD (0.54) HPGDMAPTRAB9AKMT2AALDH1A1
SCHEMBL7481917 0.79 ALDH1A1 (0.62) HPGDMAPTRAB9AKMT2AALDH1A1
SCHEMBL12950694 0.79 BACE1 (0.56) HPGDMAPTRAB9ABACE1KMT2A
SCHEMBL23663333 0.76 MAPT (0.64) HPGDMAPTRAB9AKMT2AALDH1A1
SCHEMBL11578160 0.75 NPC1 (0.60) HPGDMAPTRAB9AKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 HPGD 2655/4885MAPT 2884/4885RAB9A 1308/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.