SCHEMBL4284158

SCHEMBL4284158

Cc1c(C(=O)O)c2cc(=O)cc(F)c-2cn1-c1ccc(O)nc1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 1/20 0.37
ADH5 P11766 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4288252 0.88 ABCB1 (0.37) ABCB1ADH5
SCHEMBL3632665 0.83 ABCB1 (0.50) ABCB1
SCHEMBL1551329 0.83 AKR1C3 (0.37) ABCB1
SCHEMBL4316385 0.82 MEN1 (0.43) ABCB1
SCHEMBL3633358 0.78 NOTUM (0.44) ABCB1
SCHEMBL1550103 0.76 SMN1; SMN2 (0.39)
SCHEMBL1550977 0.76 DPP4 (0.32) ADH5
SCHEMBL3634622 0.75 NOTUM (0.45)
SCHEMBL1550184 0.74 ALDH1A1 (0.38)
SCHEMBL3236146 0.73 BRD4 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009156339-A1 ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS H. LUNDBECK A/S (DK) 2009-12-30 WO disclosed