SCHEMBL4284368

SCHEMBL4284368

CCOC(=O)C1CC(=O)C(C(=O)c2ccc(OC3CC3)cc2)=C(Br)C1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.45
ALDH1A1 P00352 3/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 1/20 0.39
EPHX2 P34913 3/20 0.39
HPGD P15428 1/20 0.38
MEN1 O00255 1/20 0.38
GAA P10253 1/20 0.38
MAPK1 P28482 2/20 0.36
TP53 P04637 2/20 0.36
MAPT P10636 1/20 0.36
TSHR P16473 1/20 0.36
PARP10 Q53GL7 1/20 0.36
HSP90AA1 P07900 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4289348 0.88 POLB (0.46) POLBALDH1A1KMT2AKDM4EEPHX2
SCHEMBL4282991 0.87 POLB (0.45) POLBALDH1A1KMT2AKDM4EEPHX2
SCHEMBL4286872 0.85 LMNA (0.42) POLBALDH1A1KMT2AKDM4EMEN1
SCHEMBL5321162 0.74 KMT2A (0.57) POLBALDH1A1KMT2AKDM4EEPHX2
SCHEMBL4284354 0.74 ALDH1A1 (0.46) POLBALDH1A1KMT2AKDM4EHPGD
SCHEMBL664676 0.73 POLB (0.57) POLBALDH1A1KMT2AEPHX2HPGD
SCHEMBL10147939 0.73 POLB (0.57) POLBALDH1A1KMT2AEPHX2HPGD
SCHEMBL241349 0.73 POLB (0.57) POLBALDH1A1KMT2AEPHX2HPGD
SCHEMBL4280973 0.73 ALDH1A1 (0.43) POLBALDH1A1KMT2AKDM4EHPGD
SCHEMBL4288123 0.73 LMNA (0.44) ALDH1A1KMT2AKDM4EMEN1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 POLB 4872/4885ALDH1A1 896/4885KMT2A 1397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.