SCHEMBL4286872

SCHEMBL4286872

CCOC(=O)C1CC(=O)C(C(=O)c2ccc(CC)cc2)=C(Br)C1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
KDM4E B2RXH2 4/20 0.41
ALDH1A1 P00352 5/20 0.41
KMT2A Q03164 5/20 0.41
NPC1 O15118 1/20 0.41
MEN1 O00255 3/20 0.39
POLB P06746 1/20 0.39
HTT P42858 3/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HSP90AA1 P07900 1/20 0.37
MAPK1 P28482 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
GAA P10253 1/20 0.35
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4288123 0.88 LMNA (0.44) LMNAL3MBTL1KDM4EALDH1A1KMT2A
SCHEMBL4281310 0.87 KDM4E (0.44) LMNAL3MBTL1KDM4EALDH1A1KMT2A
SCHEMBL4281502 0.86 LMNA (0.42) LMNAL3MBTL1KDM4EALDH1A1KMT2A
SCHEMBL4284368 0.85 POLB (0.45) LMNAKDM4EALDH1A1KMT2AMEN1
SCHEMBL4284354 0.77 ALDH1A1 (0.46) LMNAL3MBTL1KDM4EALDH1A1KMT2A
SCHEMBL4280973 0.76 ALDH1A1 (0.43) LMNAL3MBTL1KDM4EALDH1A1KMT2A
SCHEMBL10337538 0.74 BUB1 (0.49) KDM4EALDH1A1KMT2AMEN1MAPT
SCHEMBL4292313 0.73 ALDH1A1 (0.43) KDM4EALDH1A1KMT2AHTTMAPT
SCHEMBL4285688 0.72 ALDH1A1 (0.40) LMNAKDM4EALDH1A1KMT2AMEN1
SCHEMBL4289348 0.72 POLB (0.46) LMNAKDM4EALDH1A1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 LMNA 3975/4885L3MBTL1 2087/4885KDM4E 1987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.