Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.42 |
| ▸ | BRAF | P15056 | 7/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521638 | 0.81 | BRAF (0.47) | KDRBRAFTRPV1RAF1MAPK3 | |
| SCHEMBL1521752 | 0.79 | CDK8 (0.49) | KDRBRAFTRPV1RAF1ABL1 | |
| SCHEMBL1521974 | 0.77 | CDK8 (0.47) | KDRBRAFTRPV1RAF1MAPK3 | |
| SCHEMBL1521409 | 0.75 | FGFR4 (0.47) | KDRBRAFTRPV1ABL1RET | |
| SCHEMBL1521627 | 0.73 | KDR (0.40) | KDRBRAFTRPV1RAF1RIPK2 | |
| SCHEMBL4277338 | 0.72 | BRAF (0.47) | KDRBRAFRAF1RETFLT3 | |
| SCHEMBL4562970 | 0.71 | BRAF (0.42) | KDRBRAFRAF1RETFLT3 | |
| SCHEMBL4279196 | 0.71 | TRPV1 (0.39) | TRPV1KITPDGFRAMAPK11MAPK14 | |
| SCHEMBL4563507 | 0.71 | KRAS (0.30) | KDRBRAFRAF1 | |
| SCHEMBL4563487 | 0.70 | PARP1 (0.40) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | disclosed |