Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18321159 | 0.89 | PTGDR2 (0.49) | GPR52PTGDR2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL14109462 | 0.86 | MAPT (0.43) | GPR52PTGDR2SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL18321061 | 0.86 | HDAC6 (0.45) | PTGDR2SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL14108778 | 0.85 | TP53 (0.44) | GPR52PTGDR2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL14109365 | 0.84 | GPR52 (0.55) | GPR52RAB9AKDM4ENPC1KMT2A | |
| SCHEMBL13573312 | 0.84 | GPR52 (0.44) | GPR52PTGDR2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL14108630 | 0.84 | LMNA (0.53) | PTGDR2SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL18321066 | 0.83 | USP21 (0.57) | — | |
| SCHEMBL14109951 | 0.83 | NPC1 (0.51) | GPR52NPC1GAAALDH1A1KMT2A | |
| SCHEMBL14108608 | 0.83 | CACNA1G (0.43) | GPR52RAB9ANPC1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2530078-A1 | THIAZOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-12-05 | — | — | EP | disclosed |
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |