Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 6/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285447 | 0.79 | NPC1 (0.44) | NPC1TP53RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27940845 | 0.77 | PARP1 (0.58) | NPC1TP53RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5517143 | 0.74 | PARP1 (0.50) | KDM4EAURKARPS6KB1PARP1CYP3A4 | |
| SCHEMBL28187515 | 0.74 | BCAT2 (0.58) | NPC1TP53RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23647144 | 0.74 | PKN1 (0.47) | AURKARPS6KB1PARP1CDC7IKBKB | |
| SCHEMBL1535770 | 0.74 | CALM1 (0.52) | NPC1TP53RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL31540864 | 0.73 | PARP1 (0.41) | KDM4EPARP1IKBKB | |
| SCHEMBL15412857 | 0.73 | PARP1 (0.58) | PARP1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL17075501 | 0.73 | PARP1 (0.44) | NPC1TP53RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL16463064 | 0.72 | PARP1 (0.45) | KDM4EAURKARPS6KB1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675552-A4 | PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2009-06-03 | — | — | EP | disclosed |
| EP-1675552-A2 | PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037197-A2 | PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-04-28 | — | — | WO | disclosed |