SCHEMBL4285974

SCHEMBL4285974

CC(C)(C)OC(=O)N1CCC(O)(CCCOS(C)(=O)=O)CC1

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 16/20 0.43
GPR4 P46093 1/20 0.40
USP2 O75604 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4310359 0.92 GPR119 (0.43) GPR119GPR4USP2SMN1; SMN2
SCHEMBL13131365 0.83 GPR119 (0.43) GPR119USP2SMN1; SMN2
SCHEMBL2798559 0.81 ALDH1A1 (0.41) GPR119
SCHEMBL597478 0.81 GPR4 (0.46) GPR119GPR4USP2SMN1; SMN2
SCHEMBL1575709 0.81 CYP4F2 (0.47) GPR119GPR4USP2SMN1; SMN2
SCHEMBL13805598 0.81 GPR119 (0.42) GPR119USP2SMN1; SMN2
SCHEMBL18669304 0.80 USP2 (0.44) GPR119GPR4USP2SMN1; SMN2
SCHEMBL7169881 0.80 CYP4F2 (0.46) GPR119GPR4USP2SMN1; SMN2
SCHEMBL4836593 0.80 GPR4 (0.45) GPR119GPR4USP2SMN1; SMN2
SCHEMBL14996535 0.80 GPR119 (0.41) GPR119USP2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009131246-A1 SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS ASTELLAS PHARMA INC. (JP) 2009-10-29 WO disclosed
WO-2009131246-A1 SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS ASTELLAS PHARMA INC. (JP) 2009-10-29 WO disclosed