Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | OXTR | P30559 | 6/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GNRHR | P30968 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281013 | 0.87 | PTGFR (0.36) | RENMEN1KMT2AMAPTKDM4E | |
| SCHEMBL4281001 | 0.87 | DHODH (0.36) | MEN1KMT2AMAPTKDM4EATM | |
| SCHEMBL4284957 | 0.87 | MEN1 (0.35) | MEN1KMT2AMAPTKDM4EATM | |
| SCHEMBL4282562 | 0.86 | GAA (0.36) | MEN1KMT2AMAPTKDM4EATM | |
| SCHEMBL4294093 | 0.85 | USP14 (0.42) | MEN1KMT2AMAPTKDM4EATM | |
| SCHEMBL4279463 | 0.84 | KDM4E (0.43) | MEN1KMT2AGNRHRMAPTKDM4E | |
| SCHEMBL2676694 | 0.81 | NOTUM (0.44) | MEN1KMT2AMAPTKDM4EATM | |
| SCHEMBL2677224 | 0.81 | GAA (0.48) | MEN1KMT2AMAPTKDM4EATM | |
| SCHEMBL1942347 | 0.81 | REN (0.42) | RENOXTRGNRHR | |
| SCHEMBL1550877 | 0.81 | ALOX12 (0.46) | MEN1KMT2AMAPTKDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415356-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | claimed |
| EP-2313391-B1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2012-12-26 | — | — | EP | claimed |
| WO-2009156339-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2009-12-30 | — | — | WO | claimed |
| US-8415356-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | disclosed |
| EP-2313391-B1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2012-12-26 | — | — | EP | disclosed |
| WO-2009156339-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2009-12-30 | — | — | WO | disclosed |