Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.47 |
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | HTR2B | P41595 | 6/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA4 | P22748 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286502 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4ESIGMAR1HTR2AHTR2C | |
| SCHEMBL5557489 | 0.85 | MEN1 (0.44) | SMN1; SMN2KDM4ESIGMAR1HTR2AHTR2C | |
| SCHEMBL13705082 | 0.85 | MEN1 (0.44) | SMN1; SMN2KDM4ESIGMAR1HTR2AHTR2C | |
| SCHEMBL5557490 | 0.85 | MEN1 (0.44) | SMN1; SMN2KDM4ESIGMAR1HTR2AHTR2C | |
| SCHEMBL5557497 | 0.85 | MEN1 (0.44) | SMN1; SMN2KDM4ESIGMAR1HTR2AHTR2C | |
| SCHEMBL18894086 | 0.85 | AGTR2 (0.49) | SMN1; SMN2SIGMAR1AGTR2MEN1KMT2A | |
| SCHEMBL15279943 | 0.85 | AGTR2 (0.49) | SMN1; SMN2SIGMAR1AGTR2MEN1KMT2A | |
| SCHEMBL3493764 | 0.85 | AGTR2 (0.49) | SMN1; SMN2SIGMAR1AGTR2MEN1KMT2A | |
| SCHEMBL3496353 | 0.80 | SIGMAR1 (0.54) | SIGMAR1AGTR2KMT2ALMNACA1 | |
| SCHEMBL28429512 | 0.80 | SIGMAR1 (0.54) | SIGMAR1AGTR2KMT2ALMNACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | SMN1; SMN2 4811/4885KDM4E 760/4885SIGMAR1 3163/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | SMN1; SMN2 4811/4885KDM4E 760/4885SIGMAR1 3163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.