Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CYBB | P04839 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.54 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.54 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8786021 | 0.89 | MAOB (0.61) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL23781330 | 0.86 | HTT (0.77) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL30270528 | 0.86 | HTT (1.00) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL619633 | 0.86 | HTT (1.00) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL15176755 | 0.84 | HTT (0.75) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL5913175 | 0.84 | HTT (0.69) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL750896 | 0.84 | ALDH1A1 (1.00) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL30248834 | 0.84 | ALDH1A1 (1.00) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL4652613 | 0.82 | HTT (0.76) | HTTALDH1A1LMNAHPGDPOLB | |
| SCHEMBL2204998 | 0.81 | HTT (0.69) | HTTALDH1A1LMNAHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| EP-1971596-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | Takeda Pharmaceutical Company Limited (JP) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |
| EP-1419155-B1 | PIPERIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2006-11-08 | — | — | EP | disclosed |
| US-20040198756-A1 | Medicaments | SMITHKLINE BEECHAM PLC (GB) | 2004-10-07 | — | — | US | disclosed |
| EP-0463945-B1 | Chalcone derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-12-27 | — | — | EP | disclosed |
| US-5179091-A | Anti-inflammatory; antioxidant | ADIR ET COMPAGNIE (FR) | 1993-01-12 | — | — | US | disclosed |
| EP-0463945-A1 | Chalcone derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198756-A1 | Medicaments | PIGO, PSAP, CD68 | HTT 4369/4885ALDH1A1 1066/4885LMNA 3982/4885 |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | NR3C2, NR3C1, MC2R | HTT 3165/4885ALDH1A1 2708/4885LMNA 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.