Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764018 | 1.00 | AKR1B1 (0.34) | AKR1B1MPILMNAL3MBTL1TDP1 | |
| SCHEMBL2635114 | 1.00 | AKR1B1 (0.34) | AKR1B1MPILMNAL3MBTL1TDP1 | |
| SCHEMBL8836136 | 0.88 | AKR1B1 (0.37) | AKR1B1MPILMNAL3MBTL1 | |
| Pyrimidine SCHEMBL15016220 | 0.86 | — | — | |
| SCHEMBL770242 | 0.84 | LMNA (0.39) | AKR1B1MPILMNAL3MBTL1TDP1 | |
| SCHEMBL10713437 | 0.84 | LMNA (0.39) | AKR1B1MPILMNAL3MBTL1TDP1 | |
| SCHEMBL2635169 | 0.84 | LMNA (0.39) | AKR1B1MPILMNAL3MBTL1TDP1 | |
| SCHEMBL17635816 | 0.82 | MPI (0.32) | MPI | |
| SCHEMBL4726972 | 0.82 | AKR1B1 (0.33) | AKR1B1LMNAL3MBTL1TDP1USP2 | |
| SCHEMBL3408591 | 0.80 | AKR1B1 (0.34) | AKR1B1MPILMNAL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186839-A1 | Model for studying the role of genes in chemoresistance | COLD SPRING HARBOR LABORATORY (US) | 2009-07-23 | — | — | US | disclosed |
| US-20060294604-A1 | Model for studying the role of genes in tumor resistance to chemotherapy | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-12-28 | — | — | US | disclosed |
| EP-1137796-A4 | MICROMONOSPORA ECHINOSPORA GENES ENCODING FOR BIOSYNTHESIS OF CALICHEAMICIN AND SELF-RESISTANCE THERETO | SLOAN KETTERING INSTITUTEFOR C (US) | 2005-05-25 | — | — | EP | disclosed |
| US-6733998-B1 | FOR PROTEINS AND ENZYMES USED IN BIOSYNTHETIC PATHWAY AND CONSTRUCTION OF ARYLTETRASACCHARIDE AND AGLYCONE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2004-05-11 | — | — | US | disclosed |
| EP-1356026-A2 | MICROMONOSPORA ECHINOSPORA GENES ENCODING FOR BIOSYNTHESIS OF CALICHEAMICIN AND SELF-RESISTANCE THERETO | Sloan-Kettering Institute For Cancer Research (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002079465-A2 | MICROMONOSPORA ECHINOSPORA GENES ENCODING FOR BIOSYNTHESIS OF CALICHEAMICIN AND SELF-RESISTANCE THERETO | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2002-10-10 | — | — | WO | disclosed |
| EP-1137796-A2 | MICROMONOSPORA ECHINOSPORA GENES ENCODING FOR BIOSYNTHESIS OF CALICHEAMICIN AND SELF-RESISTANCE THERETO | Sloan-Kettering Institute For Cancer Research (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000037608-A2 | MICROMONOSPORA ECHINOSPORA GENES ENCODING FOR BIOSYNTHESIS OF CALICHEAMICIN AND SELF-RESISTANCE THERETO | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2000-06-29 | — | — | WO | disclosed |