Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11337662 | 0.85 | L3MBTL1 (0.46) | ALDH1A1TSHRHSD17B10L3MBTL1CASP3 | |
| SCHEMBL4131695 | 0.81 | L3MBTL1 (0.64) | ALDH1A1TSHRHSD17B10L3MBTL1CASP3 | |
| SCHEMBL9185211 | 0.74 | CYP3A4 (0.65) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL2358122 | 0.74 | CYP3A4 (0.65) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL8423197 | 0.73 | CYP3A4 (0.63) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL2358545 | 0.73 | CYP3A4 (0.63) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL2363794 | 0.73 | ALDH1A1 (0.63) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL9471700 | 0.73 | CYP3A4 (0.63) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL9693524 | 0.73 | CYP3A4 (0.63) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 | |
| SCHEMBL9693536 | 0.72 | CYP3A4 (0.61) | CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | CYP3A4 2751/4885ALDH1A1 2329/4885TSHR 876/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | CYP3A4 2751/4885ALDH1A1 2329/4885TSHR 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.