Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 6/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.45 |
| ▸ | SI | P14410 | 6/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287498 | 0.89 | EGLN3 (0.50) | GAACYP2C9CYP2C19EGLN3MGAM | |
| SCHEMBL13705095 | 0.84 | GAA (0.42) | GAACYP2C9CYP2C19EGLN3MGAM | |
| SCHEMBL4295876 | 0.79 | EGLN3 (0.46) | CYP2C9CYP2C19EGLN3APAF1NPC1 | |
| SCHEMBL4295875 | 0.79 | EGLN3 (0.46) | CYP2C9CYP2C19EGLN3APAF1NPC1 | |
| SCHEMBL4295031 | 0.79 | KMO (0.46) | RAB9APOLBNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL4294538 | 0.74 | RAB9A (0.49) | CYP2C9CYP2C19RAB9APOLBMEN1 | |
| SCHEMBL4290072 | 0.73 | EGLN3 (0.50) | CYP2C9CYP2C19EGLN3APAF1NPC1 | |
| SCHEMBL1177889 | 0.72 | CYP2D6 (0.49) | RAB9ANPC1SLC9A1GRM2MAPT | |
| SCHEMBL3495230 | 0.72 | CA1 (0.62) | POLBMEN1KMT2AFAAH | |
| SCHEMBL4749948 | 0.72 | CA1 (0.62) | POLBMEN1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | GAA 1381/4885CYP2C9 40/4885CYP2C19 19/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | GAA 1381/4885CYP2C9 40/4885CYP2C19 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.