SCHEMBL4288746

SCHEMBL4288746

NC(=O)N[C@@H]1CCOc2c(OC(F)(F)F)cccc21

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 15/20 0.59
P2RX7 Q99572 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11030125 0.79 FFAR1 (0.42) TRPV1P2RX7
SCHEMBL31715372 0.77 P2RX7 (0.46) TRPV1P2RX7
SCHEMBL3325673 0.77 TRPV1 (0.46) TRPV1P2RX7
SCHEMBL3322459 0.77 TRPV1 (0.44) TRPV1P2RX7
SCHEMBL3325669 0.77 TRPV1 (0.46) TRPV1P2RX7
SCHEMBL3322452 0.77 TRPV1 (0.44) TRPV1P2RX7
SCHEMBL15021631 0.76 TRPV1 (0.64) TRPV1
SCHEMBL15022430 0.76 TRPV1 (0.64) TRPV1
SCHEMBL15021200 0.76 TRPV1 (0.61) TRPV1
SCHEMBL2360722 0.75 TRPV1 (1.00) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090143423-A1 SOLID DISPERSION PRODUCT CONTAINING N-ARYL UREA-BASED COMPOUND ABBOTT GMBH & CO. KG (DE) 2009-06-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143423-A1 SOLID DISPERSION PRODUCT CONTAINING N-ARYL UREA-BASED COMPOUND U2SURP, UMPS, HNRNPUL1 TRPV1 4781/4885P2RX7 3712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.