Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31339766 | 0.82 | MEN1 (0.59) | MEN1KMT2ACYP11B2CYP3A4CYP11B1 | |
| SCHEMBL17896690 | 0.81 | CYP11B2 (0.46) | MEN1KMT2ACYP11B2CYP3A4CYP11B1 | |
| SCHEMBL21022943 | 0.80 | MEN1 (0.52) | MEN1KMT2ACYP3A4KDM4EALDH1A1 | |
| SCHEMBL3714642 | 0.80 | PDE10A (0.56) | MEN1KMT2ACYP3A4KDM4EALDH1A1 | |
| SCHEMBL17896708 | 0.75 | CYP11B2 (0.68) | CYP11B2CYP3A4CYP11B1 | |
| SCHEMBL1171430 | 0.75 | MEN1 (0.69) | MEN1KMT2ACYP3A4KDM4EALDH1A1 | |
| SCHEMBL6298381 | 0.75 | SMN1; SMN2 (0.49) | MEN1KMT2ACYP11B2CYP3A4CYP11B1 | |
| SCHEMBL27611222 | 0.73 | SMN1; SMN2 (0.48) | MEN1KMT2ACYP11B2CYP3A4CYP11B1 | |
| SCHEMBL1533895 | 0.73 | KDM4E (0.48) | MEN1KMT2ACYP3A4KDM4EALDH1A1 | |
| SCHEMBL22344209 | 0.73 | MEN1 (0.54) | MEN1KMT2ACYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | claimed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | claimed |