Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.68 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 7/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175463 | 0.90 | CYP11B2 (0.67) | CYP11B2CYP11B1CYP3A4SSTR5 | |
| SCHEMBL17897047 | 0.85 | CYP11B2 (0.61) | CYP11B2CYP11B1CYP3A4 | |
| SCHEMBL10175441 | 0.83 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP3A4CYP19A1 | |
| SCHEMBL463351 | 0.82 | CYP11B2 (0.67) | CYP11B2CYP11B1 | |
| SCHEMBL10175445 | 0.81 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4 | |
| SCHEMBL10175451 | 0.79 | CYP11B2 (0.63) | CYP11B2CYP11B1 | |
| SCHEMBL17896706 | 0.78 | CYP11B2 (0.61) | CYP11B2CYP11B1 | |
| SCHEMBL460559 | 0.77 | CYP11B2 (0.46) | CYP11B2CYP11B1CYP3A4CYP19A1ABL1 | |
| SCHEMBL10175449 | 0.77 | CYP11B2 (0.60) | CYP11B2CYP11B1 | |
| SCHEMBL17896690 | 0.77 | CYP11B2 (0.46) | CYP11B2CYP11B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |