Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | UGCG | Q16739 | 2/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL132355 | 1.00 | KDM4E (0.43) | KDM4ECYP1A2KMT2AMEN1CYP2C19 | |
| SCHEMBL34463743 | 1.00 | KDM4E (0.43) | KDM4ECYP1A2KMT2AMEN1CYP2C19 | |
| SCHEMBL13339371 | 1.00 | KDM4E (0.43) | KDM4ECYP1A2KMT2AMEN1CYP2C19 | |
| SCHEMBL27743245 | 0.84 | KMT2A (0.43) | KDM4ECYP1A2KMT2AMEN1GBA1 | |
| SCHEMBL15583053 | 0.81 | KMT2A (0.49) | KDM4ECYP1A2KMT2AMEN1GBA1 | |
| SCHEMBL901166 | 0.81 | KMT2A (0.50) | KDM4ECYP1A2KMT2AMEN1GBA1 | |
| SCHEMBL5376000 | 0.80 | MEN1 (0.48) | KDM4ECYP1A2KMT2AMEN1CYP2C19 | |
| SCHEMBL4367349 | 0.80 | MEN1 (0.58) | KDM4ECYP1A2KMT2AMEN1CYP2C19 | |
| SCHEMBL13367174 | 0.77 | GBA1 (0.42) | KDM4ECYP1A2KMT2AMEN1GBA1 | |
| SCHEMBL2562377 | 0.76 | CYP1A2 (0.65) | KDM4ECYP1A2KMT2AMEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102937-B2 | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA | TINA HOLDING APS (DK) | 2015-08-11 | — | — | US | disclosed |
| CN-101238213-B | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of tina | TINA HOLDING APS | 2015-05-20 | — | — | CN | disclosed |
| EP-1888748-B1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2013-08-28 | — | — | EP | disclosed |
| US-20100121056-A1 | PSEUDONUCLEOTIDE COMPRISING AN INTERCALATOR | HUMAN GENETIC SIGNATURES PTY. LTD. (AU) | 2010-05-13 | — | — | US | disclosed |
| US-20090216003-A1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2009-08-27 | — | — | US | disclosed |
| CN-101238213-A | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of tina | TINA HOLDING APS (DK) | 2008-08-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121056-A1 | PSEUDONUCLEOTIDE COMPRISING AN INTERCALATOR | POLRMT, POLN, RNASE1 | KDM4E 4143/4885CYP1A2 2291/4885KMT2A 3256/4885 |
| US-20090216003-A1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | PCNA, DNA2, NUDT1 | KDM4E 4588/4885CYP1A2 4080/4885KMT2A 1440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.