Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196554 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10TSHRSLC2A1 | |
| SCHEMBL18762948 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4EHSD17B10TSHRSLC2A1 | |
| SCHEMBL4306584 | 0.78 | MAPT (0.37) | ALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL4312601 | 0.78 | TPMT (0.32) | SMN1; SMN2 | |
| SCHEMBL4306555 | 0.75 | CES1 (0.43) | ALDH1A1KDM4EHSD17B10TSHRCYP2C9 | |
| SCHEMBL198642 | 0.73 | ALDH1A1 (0.35) | ALDH1A1KDM4EHSD17B10TSHRSLC2A1 | |
| SCHEMBL18762946 | 0.71 | ALDH1A1 (0.40) | ALDH1A1KDM4EHSD17B10TSHRSLC2A1 | |
| SCHEMBL18700961 | 0.70 | L3MBTL1 (0.56) | ALDH1A1KDM4EHSD17B10TSHRSLC2A1 | |
| SCHEMBL8764001 | 0.70 | TRPV4 (0.43) | ALDH1A1KDM4EHSD17B10TSHRL3MBTL1 | |
| SCHEMBL18700948 | 0.70 | KDM4E (0.42) | ALDH1A1KDM4EHSD17B10SLC2A1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264439-A1 | Combination of a) N--4-(3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia | DENT PAUL | 2009-10-22 | — | — | US | disclosed |
| US-20090253015-A1 | POLYARYLENE BLOCK COPOLYMER AND USE THEREOF | SUMITOMO CHEMICAL COMPANY ,LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| EP-2065420-A1 | METHOD FOR PRODUCING POLYARYLENE | Sumitomo Chemical Company, Limited (JP) | 2009-06-03 | — | — | EP | disclosed |
| EP-1857482-A1 | POLYARYLENE BLOCK COPOLYMER AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2007-11-21 | — | — | EP | disclosed |
| US-20060100140-A1 | Combination of a) n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]2-methylphenyl}-4- (3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia | NOVARTIS AG (CH) | 2006-05-11 | — | — | US | disclosed |
| CN-1681505-A | Combination of a) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia | UNIV VIRGINIA COMMONWEALTH (US) | 2005-10-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264439-A1 | Combination of a) N--4-(3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia | HDAC5, HDAC2, HDAC1 | ALDH1A1 1337/4885KDM4E 76/4885HSD17B10 3207/4885 |
| US-20060100140-A1 | Combination of a) n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]2-methylphenyl}-4- (3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia | HDAC5, HDAC2, HDAC1 | ALDH1A1 1563/4885KDM4E 65/4885HSD17B10 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.